现代检验医学杂志2011，Vol.26Issue(3)：17-20,4.DOI:10.3969/j.issn.1671-7414.2011.03.006
黏病毒抗性蛋白A基因多态性与HBV感染转归的关系
Association of MxA Gene Promoter Polymorphisms with the Clearance of Hepatitis B Virus Infection
张平安 1魏新素 1李艳 1严少南2
作者信息
- 1. 武汉大学人民医院检验科,武汉,430060
- 2. 武汉大学人民医院感染科,武汉,430060
- 折叠
摘要
Abstract
Objective To explore the influences of the gene polymorphisms of myxovirus resistance A(MxA) promoter on the outcome of hepatitis B virus(HBV) infection. Methods After the process of extracting genomic DNA from blood of 160 subjects who spontaneously recovered and 243 patients with chronic HBV infection,three single nucleotide polymorphism (SNP)sites in MxA promoter marked as - 88G/T, - 123C/A were determined by polymerase chain reaction (PCR) -restriction fragment length polymorphism(RFLP)analysis. Results Subjects with self-limiting infection had a lower frequency of MxA-88 GG genotype (41. 3％ vs 52. 7 ％,P= 0. 025) or G allele (62. 8 ％ vs 74. 9％ ,P = 0. 001) , and a higher frequency of TT genotype (15. 6％ vs 2. 9％ , P=0.000)or T allele (37. 2 ％ vs 25. 1％ , P = 0.001)than patients with persistent HBV infection (OR : 6. 24, 95 ％ CI: 2. 63 ～ 14. 81). However, no significant differences in the distribution of MxA -123C/A gene SNP between patients with persistent HBV infection and subjects with self-limiting HBV infection were observed (P ＞0. 05). Conclusion There is an association between polymorphisms of the promoter region -88G/T of MxA and the resolution of HBV infection. The presence of the TT genotype or T allele in MxA promoter -88 sites may be resistant to HBV infection,which gives some new clues to the study of pathogenesis of persistent HBV infection.关键词
乙型肝炎病毒/黏病毒抗性蛋白A/单核苷酸多态性Key words
hepatitis B virus / myxovirus resistance A / single nucleotide polymorphism分类
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张平安,魏新素,李艳,严少南..黏病毒抗性蛋白A基因多态性与HBV感染转归的关系[J].现代检验医学杂志,2011,26(3):17-20,4.
