老年医学与保健2011，Vol.17Issue(3)：152-154,3.DOI:10.3969/j.issn.1008-8296.2011-03-08
基于三维适形放疗技术研究剂量递增治疗局部晚期非小细胞肺癌的效果
Effect of the maximal tolerance dose of dose escalation on non-small cell lung cancer through 3-dimensional conformal radiation therapy
摘要
Abstract
Objective To investigate the role of maximal tolerance dose (MTD) of dose escalation in non-small cell lung cancer (NSCLC). Methods 30 patients with NSCLC with stage Ⅱ and stage Ⅲ were enrolled via dose escalation of NSCLC through 3-dimensional conformal radiation therapy. The scheduled dose escalation ranged from 68 Gy to 76 Gy.The percentage of normal lung volume which received 20 Gy was less than 37 ％ . When 1 case of 5-patient-group developed ≥3 grade acute reaction, this group of dose escalation would be repeated. Results 30 patients were enrolled in the test and completed the treatment. The overall survival of 1, 2, 3- year were 66.7 ％ , 40 ％and 30 ％ , respectively. The median survival was 18.3 months. Conclusions Dose escalation for NSCLC through 3-dimensional conformal radiotherapy could be accepted without excessive toxicity, and may improve overall survival rates of patients with stage Ⅱ and Ⅲ NSCLC.关键词
非小细胞肺癌/三维适形放射治疗/剂量递增Key words
Non-small cell lung cancer/ 3-D conformal radiation therapy/ Dose escalation分类
医药卫生引用本文复制引用
傅美娜..基于三维适形放疗技术研究剂量递增治疗局部晚期非小细胞肺癌的效果[J].老年医学与保健,2011,17(3):152-154,3.基金项目
复旦大学附属华东医院院级课题(H-277) （H-277）
