中国组织工程研究与临床康复2011，Vol.15Issue(24)：4371-4374,4.DOI:10.3969/j.issn.1673-8225.2011.24.001
点种法移植软骨细胞修复关节软骨缺损
Point implantation of allograft chondrocytes for repairing articular cartilage defects
陈义泉 1沈惠良 2雍宜民 2胡怀建2
作者信息
- 1. 深圳市龙岗区第二人民医院骨科,广东省深圳市518112
- 2. 首都医科大学附属宣武医院骨科,北京市100053
- 折叠
摘要
Abstract
BACKGROUND: Although many biological reconstruction can repair defects and rebuild articular surfaces, the function is inferiorto normal cartilage. Transplantation of biodegradable polymer-coated cartilage cells may obtain real hyaline cartilage.OBJECTIVE: To observe effects of collagen-embedded chondrocytes by point implantation method on repairing articularcartilage defects.METHODS: Articular cartilage defects were made in the knee of New Zealand rabbits. The rabbits were randomly divided intothree groups, treated with collagen gel-embedded chondrocytes, chondrocytes or no treatment.RESULTS AND CONCLUSION: Histological changes were observed at 2, 4, 12 and 24 weeks postoperatively. Hyaline cartilagewas observed in rabbits following transplantation of collagen gel-embedded chondrocytes, while only fibrous tissues wereobserved in the defects in the other two groups. Moreover, mean histological and histochemical scores were greater in the rabbitstreated with collagen gel-embedded chondrocytes compared with the other groups (P ＜ 0.01). Results show that transplantationof collagen gel-embedded chondrocytes can obtain hyaline cartilage, and can be used for repairing large-area cartilage defects.关键词
胶原包埋/点种法:软骨下骨钻孔/关节软骨缺损/移植/修复分类
医药卫生引用本文复制引用
陈义泉,沈惠良,雍宜民,胡怀建..点种法移植软骨细胞修复关节软骨缺损[J].中国组织工程研究与临床康复,2011,15(24):4371-4374,4.
