世界中医药2011，Vol.6Issue(4)：340-342,3.
三七总皂苷联合三苯氧胺对乳腺癌T47D细胞生长与凋亡影响
Impact of Panax Notoginsenosidum and Tamoxifen on Breast Cancer T47D Cell
黄梅 1杨丽娟 1谢丹1
作者信息
- 1. 广州中医药大学第一附属医院乳腺科,广东省广州市机场路16号大院,510405
- 折叠
摘要
Abstract
Objective:To investigate impact of Panax Notoginsenosidum and Tamoxifen ( TAM ) on breast cancer T47D Cell. Methods:Different concentration of TAM and Panax Notoginsenosidum were administered to T47D Cell. The cell growth inhibition was assessed by MTT, the cell cycle distribution and apoptosis rate were assessed by FCM. Results: Panax Notoginsenosidum and Tamoxifen ( TAM ) can respectively inhibit growth of T47D cell, positively correlated with higher concentration and increasing time. TAM 1.5 x 10-5mol/L on top of 3 different concentration of Panax Notoginsenosidum had more significant inhibition than used alone. Both can reduce amount of cell at cycle S in comparison with blank control group. Moreover, combined use had the tendency to stimulate apoptosis. Conclusion:Panax Notoginsenosidum has direct, time and concentration dependent inhibition effect on breast cancer T47D Cell. High dose of Panax Notoginsenosidum can enhance anti-tumor effect of TAM by impacting cell cycle and apoptosis.关键词
乳腺肿瘤/细胞周期/凋亡/三苯氧胺/三七总皂苷Key words
Breast cancer/ Cell Cycle/ apoptosis/ Panax Notoginsenosidum/ Tamoxifen引用本文复制引用
黄梅,杨丽娟,谢丹..三七总皂苷联合三苯氧胺对乳腺癌T47D细胞生长与凋亡影响[J].世界中医药,2011,6(4):340-342,3.
