世界中医药2011，Vol.6Issue(4)：343-346,4.
脑缺血-再灌注相关细胞因子表达的TNF-α损伤机制及清开灵的作用
Impairment Mechanism of TNF-α in Ischemia-reperfusion Rats and Effect of Qingkailing
庞春红 1李澎涛 2朱晓磊3
作者信息
- 1. 中日友好医院病理科,北京市朝阳区樱花东路
- 2. 北京中医药大学
- 3. 世界中医药学会联合会
- 折叠
摘要
Abstract
Objective :To investigate impairment mechanism of TNF-α in ischemia-reperfusion rats and effect of Qingkailing. Methods:The ischemia-reperfusion model of rats was established by performing double common carotid clamping on adult male Wistar rats. Qingkailing, antibody-TNF-α, Qingkailing + anti-TNF-α were receptively administered to the model. We observed serum TNF-α、 serum sICAM-1 、serum p-selectin and expression of brain tissue ICAM-1 at 24h and 72h. Results: A tendency was observed in Qingkailing to reduce the increasing level of serum TNF-α, which intensified over time. Qingkailing and antibody-TNF-α can reduce expression of peripheral blood sICAM-1 、P-selectin, and brain tissue ICAM-1. The effect was more obvious after blocking TNF-α, and the effect of Qingkailing was more significant. Conclusion: The BBB injury due to cerebral ischemia-reperfusion is related closely to the toxicity of inflammary- cytokine inside and outside the blood capillary, and also related to the adherence between white blood cells and endothelial cells caused by adhesion molecule.关键词
缺血-再灌注/TNF-α/TNF-α抗体/清开灵Key words
Ischemia reperfusion/ TNF-α/ TNF-αantibody/ Qingkailing引用本文复制引用
庞春红,李澎涛,朱晓磊..脑缺血-再灌注相关细胞因子表达的TNF-α损伤机制及清开灵的作用[J].世界中医药,2011,6(4):343-346,4.
