中国组织工程研究与临床康复2011，Vol.15Issue(24)：4405-4408,4.DOI:10.3969/j.issn.1673-8225.2011.24.009
构建大腿软组织损伤模型兔与跌创散的修复作用
Construction of rabbit models with thigh soft tissue injury and repair effect of traditional Chinese medicine Diechuangsan
张贵富 1王志义 2刘丹平3
作者信息
- 1. 辽宁医学院研究生学院,辽宁省锦州市,121001
- 2. 锦州石化医院,辽宁省锦州市121001
- 3. 辽宁医学院附属第一医院骨科,辽宁省锦州市,121001
- 折叠
摘要
Abstract
BACKGROUND: Traditional Chinese medicine Rheum palmatum L. and Cortex Phellodendri Chinensis have the property of activating blood circulation and removing stasis, as well as deswelling and alleviating pain, which obtain good outcomes in treating soft tissue injury.OBJECTIVE: To study the effect of Diechuangsan (DCS) on experimental soft tissue injury and prostaglandin E2 expression.METHODS: Totally 36 New Zealand big ear white rabbits were randomly divided into 3 groups, namely, DCS, model and control groups. Rabbits were established acute soft tissue injury models and treated by DCS at 30 minutes after model preparation, once per day. No medication was performed in the model and control groups. Prostaglandin E2 expression and hemorheology index changes were observed at 5 days after model preparation. The recovery of injured soft tissues was observed by hematoxylin-eosin staining and pathological score at 5 and 13 days after model preparation.RESULTS AND CONCLUSION: Compared with the model group, the pathological score of the DCS group was higher (P ＜ 0.05), which was earlier close to the normal tissues. In addition, the prostaglandin E2 expression and blood viscosity of the DCS group was lower than that of the model group (P ＜ 0.05). It is suggested that DCS can repair injured soft tissues via decreasing inflammatory mediators prostaglandin E2 and reducing injury animal blood viscosity.关键词
软组织损伤/中药/前列腺素E2/血液黏度/修复分类
医药卫生引用本文复制引用
张贵富,王志义,刘丹平..构建大腿软组织损伤模型兔与跌创散的修复作用[J].中国组织工程研究与临床康复,2011,15(24):4405-4408,4.
