中国组织工程研究与临床康复2011，Vol.15Issue(24)：4415-4418,4.DOI:10.3969/j.issn.1673-8225.2011.24.011
自体富含血小板血浆对兔骨折愈合的影响
Role of autologous platelet-rich plasma on fracture healing in rabbits
周海洋 1王宸 1耿震1
作者信息
- 1. 东南大学附属中大医院骨科,江苏省南京市,210009
- 折叠
摘要
Abstract
BACKGROUND: Platelet-rich plasma (PRP) is often prepared with autalloploid and can be used to promote the fracture healing of flat bone and cancellous bone.OBJECTIVE: To prepare PRP with Landsberger’s method and to analyzes the therapeutic role of PRP on the fracture healing of radius in rabbits.METHODS: New Zealand rabbits were randomly divided into a control group and a PRP treated group. Unilateral open femoral fracture models were established in the lower 1/3 radius bone. PRP group received was treated with autologous PRP gel, while control group was only sutured after fracture modeling. Autologous PRP was prepared by Landsberger’s method and then implanted to the fracture site, followed by plaster immobilization of the fracture fragments.RESULTS AND CONCLUSION: The fracture specimens exhibited varying degrees of callus formation at 1, 2, 4, 6 weeks. X-ray score in the PRP group was significantly higher than that in control group at 4 weeks (P ＜ 0.05). Immunohistochemistry showed that, type I collagen content in the PRP treatment group was significantly higher than that in the control groups for 4 weeks (P ＜0.05). PRP accelerates bone fracture healing of rat femurs by increasing expression of type I collagen and the number of bone island.关键词
富含血小板血浆/长骨/骨折愈合/成骨细胞/血小板源性细胞因子/Ⅰ型胶原/纤维蛋白/组织构建分类
医药卫生引用本文复制引用
周海洋,王宸,耿震..自体富含血小板血浆对兔骨折愈合的影响[J].中国组织工程研究与临床康复,2011,15(24):4415-4418,4.
