四川医学2011，Vol.32Issue(5)：621-623,3.
LXRα激活剂T0901317对急性肺损伤大鼠肺组织MPO、TNF-α表达的影响
Influence of liver X receptor-α activator T0901317 on expression of MPO and TNF-α in rat lung with acute lung injury
摘要
Abstract
Objective To investigate inhibitory action of T0901317, a liver X receptor-α activator, on expression of MPO and TNF-α in rats with acute lung injury (ALI). Methods 72 male Wistar rats were randomly divided into three group: control group (C group), LPS group (L group), T0901317 group (LT group). The rats were killed at lb, 2h, 4h, 8h after treatment. The lung tissue was collected, myeloperoxidase activity, lung histopathologic changes and expression of TNF-α were observed. Results In rats with ALI, myeloperoxidase activity rised compared with control group (P ＜ 0. 05 ), and lung injury is more severe than that in rats of control group. TNF-α increased markedly in lung homogenate and blood serum at the same period ( P ＜ 0. 05 ). However, The expression of TNF-α and myeloperoxidase activity in rat lung tissues in LT group were significantly declined. Conclusion T0901317 has played an anti-inflammatory effect through suppressing the expression of TNF-α and myeloperoxidase activity in rat lung with acute lung injury .关键词
T0901317/急性肺损伤(ALI)/髓过氧化物酶(MPO)/肿瘤坏死因子-α(TNF-α)Key words
T0901317/ acute lung injury/ myeloperoxidase activity/ TNF-α分类
医药卫生引用本文复制引用
徐静,李运成,何春琳,肖波,王建春..LXRα激活剂T0901317对急性肺损伤大鼠肺组织MPO、TNF-α表达的影响[J].四川医学,2011,32(5):621-623,3.基金项目
国家自然科学基金资助项目(编号:30570SOS) （编号:30570SOS）
