四川医学2011，Vol.32Issue(5)：633-636,4.
抗结核药物引起药物性肝损害的临床特点分析
The clinical characteristic of antituberculosis drug-induced liver injury and its relationship with gene polymorphism of drug metabolizing enzymes
摘要
Abstract
Objective To study the clinical characteristics and predisposing factor of antituberculosis drug-induced liver injury. Methods The clinical characteristics and correlative factors of 2457 cases with tuberculosis ( TB) who had been inpatiented for initial treatment between 2005 and 2009 were retrospectively analyzed. Results Of the 2457 TB patients who received initial treatment,267 ( 10. 9％ ) patients had antituherculosis drug-induced liver injury;13. 6％ ( 148/1085 ) female patients had antituberculosis drug-induced liver injury , which was significantly higher than the male patients ( 8. 7％ , 119/1372 ,P ＜ 0. 05 ) . Of the TB patients who accepted the liver protectant, the incidence of antituberculosis drug-induced liver injury was 10. 0％ ( 187/1876) ,which was significantly lower than in the control ( 13. 8％ , 80/581 ,P ＜ 0. 05 ) . The incidence of antituberculosis drug-induced liver injury in TB patients treated with HRZ regime ( 13. 2％ ,139/1050) was significantly higher than that in TB patients treated with HR regime (9. 1％ ,128/1407 ,P ＜ 0. 05 ) . Conclusion The female patients with TB may he easy to develop to antituberculosis drug-induced liver injury. The rational use of liver protectant may reduce the incidence of antituberculosis drug-induced liver injuryⅠ. The incidence of antituberculosis drug-induced liver injury in the patients treated with HRZ regime was higher than that in the patients treated with HR regime.关键词
肝损害/抗结核药物/临床特点/易感因素Key words
liver injury / anti-tuberculosis drugs / clinical characteristics / predisposing factor分类
医药卫生引用本文复制引用
安慧茹,吴雪琼,王仲元,徐静,郑少华,王坤..抗结核药物引起药物性肝损害的临床特点分析[J].四川医学,2011,32(5):633-636,4.基金项目
北京市科技计划研发攻关类科研基金资助项目(编号:D08050700640802) （编号:D08050700640802）
