重庆医学2011，Vol.40Issue(19)：1894-1896,3.DOI:10.3969/j.issn.1671-8348.2011.19.008
同步放化疗联合中药健脾补肾法治疗局部晚期非小细胞肺癌临床研究
Clinical observation of concurrent chemoradiotherap combination chinese medicine to invigorate the spleen and the kidney for locally advanced non-small cell lung cancer
任洪波 1缪剑华 2袁经权 2夏春生 1黄碧有 1包中会 1田敏 1李少林3
作者信息
- 1. 重庆市巴南区第二人民医院肿瘤科,400054
- 2. 广西壮族自治区药用植物园,南宁,530023
- 3. 重庆医科大学放射肿瘤学教研室,400016
- 折叠
摘要
Abstract
Objective To observe the effect and side efects of concurrent chemoradiotherapy for concurrent chemoradiotherap combination Chinese medicine to invigorate the spleen and the kidney for locally advanced non-small cell lung cancer.Methods 126 patients were randomly allocated into 2 groups.The therapy group( concurrent chemoradiotherapy combination Chinese medicine) ens 68 patients( Ⅲ a stage 28 cases, Ⅲ b stage 40 cases) ,the radiotherapy and chemotherapy was carried out the same as the Concurrent chemoradiotherap group,i. e.firstly with pacjitaxel l35mg/m2 iv dl , cisplatin 60mg/m2 iv d3, repeated every 28 days, total 4cycle.After the chemotherapy to end take orally Sanjiao Fuzheng Heji 250ml once daily, when the disease progress to stop take orally Sanjiao Fuzheng Heji.Results All patients were followedup for more than five years.The followed-up rate was 95.24％.In the therapy group,the 3-year survival rate and the 5-year survival rate were 49.52％ and 21.49％ , MST 22 months.In the concurrent chemoradiotherapy group the 3-year survival rate and the 5-year survival rate were 36.73％ and15.14％ , MST 17 months.There was significant difference in two groups(P＜0.05 , x2 = 4.94 ; x2 = 5.94 ,P＜0.05).In the therapy group the Ⅲ - Ⅳ leucocyte decrease rate were 20.59％ ; radiation pneumonia were 13.23％ ;In the concurrent chemoradiotherapy group the Ⅲ - Ⅳ leucocyte decrease rate were 72.41％ ; radiation pneumonia were 13.23％ ; radiation esophagitis were 30.88％.There was significant difference in two groups(P＜0.05).Conclusion Concurrent Chemoradiotherapy combination Chinese medicine for advanced locally advanced non-small cell lung cancer can significantly improve the 3-year and 5-year survival rate and has degrade in toxicityside effect.关键词
癌/非小细胞肺/同步放化疗/放射治疗/化学治疗Key words
carcinoma , non-small cell lung / concurrent chemoradiotherapy/ radiotherapy/ chemotherapy引用本文复制引用
任洪波,缪剑华,袁经权,夏春生,黄碧有,包中会,田敏,李少林..同步放化疗联合中药健脾补肾法治疗局部晚期非小细胞肺癌临床研究[J].重庆医学,2011,40(19):1894-1896,3.
