四川医学2011，Vol.32Issue(5)：647-649,3.
Egb761对哮喘大鼠mmp-9表达的影响和气道炎症的干预作用
The role of Egb761 on the expression of matrix metalloproteinase-9 in asthmatic rats models and the intervention of airway inflammation
王家珍 1吴天清 1林荣1
作者信息
- 1. 三台县人民医院重症医学科,四川,三台,621100
- 折叠
摘要
Abstract
Objective To investigate the effects of ginkgo bioba extract( Egb761 ) on matrix metalloproteinase-9 (mmp-9)expression and evaluate the intervention effect on airway inflammation in asthmatic rats model. Methods 40 SD rats were randomly divided into 4 groups: normal control group( group A), asthmatic model group( group B), dexamethasone group( group C)and Egb761 group( group D) . The models of asthma were established by repeated inhalation of ovalbulium. The expression of MMP-9 in bronchial epithelium in these groups were determined using immunohistochemical technique and computer assisted image analysis system . The Eos amounts and differential leukocytes counts in bronchoalveolar lavage fluid(BALF) were counted. Results ①The expression of mmp-9 in the epithelial cells of bronchi was significantly higher in the asthmatic group than normal control group(P ＜ 0. 05) . The expression of mmp-9 in Egb761 group was much lower than that in asthmatic model group(P ＜0. 05 ). There were no statistical significant difference between dexamethasone group and Egb761 group( P ＞ 0. 05 ). ②The Eos amounts in BALF of Egb761 group was much lower than that in asthmatic model group( P ＜ 0. 05 ). There were no statistical significant difference between dexamethasone group and Egb761 group (P ＞ 0. 05 ). Conclusion Egb761 could inhibit the expression of mmp-9 and decrease airway inflammation in asthmatic rats.关键词
银杏叶提取物/基质金属蛋白酶/气道炎症/哮喘Key words
ginkgo bioba extract/ matrix metalloproteinase-9/ airway inflammation/ asthma分类
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王家珍,吴天清,林荣..Egb761对哮喘大鼠mmp-9表达的影响和气道炎症的干预作用[J].四川医学,2011,32(5):647-649,3.
