四川医学2011，Vol.32Issue(5)：661-662,2.
拉米夫定治疗102例慢性重度乙型肝炎近期疗效观察
Short-term efficacy of lamivudine for 102 patients with chronic severe-degree hepatitis B
胡章勇 1杨军 1黄赛 1夏绍碧 1刘福元1
作者信息
- 1. 成都医学院第一附属医院感染科,四川,成都,610500
- 折叠
摘要
Abstract
Objective To evaluate the effect of lamivudine for patients with chronic severe-degree hepatitis B. Methods 197 patients with chronic severe-degree hepatitis B were randomly divided into a conventional supporting treatment control group and a lamivudine treatment group. In the latter,102 patients were given lamivudine orally at a dose of 100mg every day besides the support care which was also given to the control group. Results After therapy for 8 weeks, total hiliruhin and alanine aminotransferase levels of lamivudine group was lower than that in control group ( P ＜ 0. 01) , the serum HBV DNA levels were decreased more rapidly in the lamivudine treatment group ( P ＜ 0. 01 ) , meanwhile . PTA increased less obviously in cntrol group ( P ＜ 0. 01 ) .There was a significant difference between the two groups in regards to the complication incidence of gastrointestinal bleeding,spontaneous bacterial peritonitis , hepatorenal syndrome and hepatic coma. Furthermore , the mortality and the rate of severe hepatitis incidence in lamivudine group was lower than that of control group. Conclusion Lamivudine treatment can partially preventchronic severe hepatitis occurrence in patients with chronic severe-degree hepatitis B.increase the survival rate and decrease the rate of complication.关键词
慢性重度乙型肝炎/DNA病毒/治疗/拉米夫定Key words
chronic hepatitis B / DNA virus / treatment / lamivudine分类
医药卫生引用本文复制引用
胡章勇,杨军,黄赛,夏绍碧,刘福元..拉米夫定治疗102例慢性重度乙型肝炎近期疗效观察[J].四川医学,2011,32(5):661-662,2.
