摘要
Abstract
Objective Investigate the levels of serum adiponectin (APN),IL-6,IL-17,CRP among gestational diabetes mellitus (GDM) and healthy gestational women,and analyse their relationship,in addition explore the possible significaence of adiponectin in the development of gestational diabetes mellitus. Methods To select 60 women with GDM,39 healthy gestational women,and 45 healthy women,all subjects were divided with ADA diagnosis standard. The APN and IL-6,IL-17 were detected with ELISA , and CRP with immunoturbidimetry. Results ①Compared with NGT group,adiponectin in noGDM and GDM group were significantly lower(P＜0. 05,P＜0.01) ,and GDM group compared with the GDM group drop more obvious (P＜0. 01) ,but CRP,IL-6 and IL-l7 were higher (P＜0.01,P＜0.01,P＜0. 05) ; and GDM group compared with the no-GDM group increased significantly difference ,with a statistical significance (P＜0. 05,P＜0. 05, P＜0. 01) ;②The serum APN level was lower in late generational of GDM than early generational of GDM (P＜0. 05),but CRP,IL-6 and IL-17 were increased obviously (P＜0.01,P＜0.01,P＜0.01). ③Negative associations were found between APN and IL-6,IL-17 and CRP. Conclusion Significant negative correlation showed between adiponectin and inflammatory factors,this indicate that inflammation and anti-inflammatory imbalances mechanisms involved in women with gestational diabetes mellitus events.关键词
脂联素/妊娠糖尿病/白介素-6/白介素-17/C-反应蛋白Key words
adiponectin/gestational diabetes mellitus / IL-6 /IL-17 / CRP分类
医药卫生
