中国组织工程研究与临床康复2011，Vol.15Issue(24)：4473-4476,4.DOI:10.3969/j.issn.1673-8225.2011.24.025
高原低氧对大鼠心肺组织超微结构的影响
High altitude hypoxia on the ultrastructure of heart and lung tissue
摘要
Abstract
BACKGROUND: Studies show that, the body inevitably will be injured to different degrees upon the rapid access to high altitude,among them damage to heart and lung is apparent.OBJECTIVE: To evaluate the influence of hypoxic acclimatization on the ultrastructure of rat heart and lung.METHODS: SD rats were randomly divided into 4 groups, namely the plateau hypoxia 1, 3, 30 days, and a control group. The hypoxic groups of rats were brought from the Xi'an (elevation 5 m), to Golmud, Qinghai (elevation 2 700 m; 1 day), to the Naqu (elevation 4 500 m; time-consuming 3 and 30 days). The cardiopulmonary specimens were observed for the histological changes.RESULTS AND CONCLUSION: At acute hypoxia 1 and 3 days, the microstructure and ultrastructure of lung tissues exhibited apparent interstitial pulmonary edema and alveolar pulmonary edema; rat ventricular myocytes showed varying degrees of cloudy swelling, vacuolar degeneration, necrosis and interstitial dissolved edema by the heart tissue observations under light microscopy; electron microscope displayed that, the mitochondria swelling, sarcoplasmic reticulum, myofibril dissolution,intracellular and extracellular edema in cardiac muscle cells. These changes in the right ventricular wall at hypoxia 3 days were more apparent compared with those in left ventricular wall. The interstitial edema after hypoxic acclimatization was significantly reduced at 30 days. High altitude acute hypoxia may induce pulmonary interstitial edema and alveolar pulmonary edema, as well as right ventricular-based heart damage. The heart and lung tissue lesions significantly reduced after high altitude hypoxic acclimatization.关键词
习服/高原低氧/大鼠/电镜/超微结构/组织工程分类
医药卫生引用本文复制引用
张春爱,李文华..高原低氧对大鼠心肺组织超微结构的影响[J].中国组织工程研究与临床康复,2011,15(24):4473-4476,4.基金项目
课题受西藏自治区科技厅自然科学基金项目(2010) 资助,人类血浆AVP 基因多态性与高原习服的相关性及其影响因素研究. （2010）
