中国组织工程研究与临床康复2011，Vol.15Issue(24)：4485-4488,4.DOI:10.3969/j.issn.1673-8225.2011.24.028
耐力运动大鼠跟腱胶原、基质金属蛋白酶1及其抑制剂1的表达
Effect of treadmill exercise on the collagen, matrix metalloproteinases-1 and tissue inhibitors of metalloproteinase-1 mRNA in rat's Achilles tendon
李敏 1金力1
作者信息
- 1. 商丘师范学院体育学院,河南省商丘市,476000
- 折叠
摘要
Abstract
BACKGROUND: Collagen is the main protein component of tendon tissue. Metalloproteinases are a large family of enzymes capable of degrading all of the tendon matrix components.OBJECTIVE: To investigate the effects of 12-week treadmill running on content of collagen and the expression of procollagen I,matrix metalloproteinases-1 (MMP-1) and tissue inhibitors of metalloproteinase-1 of rat Achilles tendon.METHODS: A total of 20 male Sprague-Dawley rats were randomly assigned to control and exercise groups. At 1 week, exercise was performed for 20 minutes daily, at the increased speed from 12 m/min to 20 m/min. The treadmill speed was kept at 20 m/min. At 2 weeks, the gradient was 5％, and time was 30 minutes. At 3-12 weeks, the gradient was 10％, and the time was 40 minutes, for totall 12 weeks. In control group, the animals were fed normally.RESULTS AND CONCLUSION: 24 hours after the last exercise, the rat Achilles tendon was obtained. Compared with control group, the expression of procollagen Iα1, MMP-1 and its inhibitor 1 mRNA was significantly increased (P ＜ 0.05 or P ＜ 0.01) in the exercise group, and the hydroxyproline content was increased (P ＞ 0.05). These results show that long-term treadmill running can increase the synthesis and degradation of collagen in achilles tendon.关键词
跑台运动/跟腱/胶原/基质金属蛋白酶1/基质金属蛋白酶组织抑制剂1分类
医药卫生引用本文复制引用
李敏,金力..耐力运动大鼠跟腱胶原、基质金属蛋白酶1及其抑制剂1的表达[J].中国组织工程研究与临床康复,2011,15(24):4485-4488,4.
