摘要
Abstract
[ Objective ] Microencapsulation was carried out for castor oil, thus, sustained-release castor oil microcapsule was prepared. [ Method ]Complex coacervation method was used, and taking gelatin and Arabic gum as capsule materials, in addition, castor oil was viewed as core materials to prepare micro-capsule. The shapes of microcapsules were observed with the help of microscope, the content of castor oil was determined based on ultraviolet spectrophotometer; and dissolution rate in vitro with water were investigated. With encapsulation efficiency as quahty evaluation index, furthermore, the prescription was optimized by single phoneme and orthogonal experiment. [ Result ] The best preparation technological conditions of sustained-release castor oil microcapsule were：the gelatin and the Arabic gum density was 7.5％, the formaldehyde amount was the 1.0 ml, pH value was 3.80, the proportion of raw material to medicine was 6∶1. According to this prescription, the shape of micro-capsule was rounding and smooth, and showed larger loading capacity, moreover, had certain sustained-release effect. [ Conclusion ] The duplicate condensation law may successfully prepared sustained-release castor oil microcapsule with higher entrapment rate, moreover, the product stability was good. The method had strong operability and good duplication, thus, had certain practical value.关键词
蓖麻油/复凝聚法/微囊化/正交试验Key words
Castor oil/ Complex coacervation/ Microencapsulation/ Orhogonal test分类
农业科技
