中国组织工程研究与临床康复2011，Vol.15Issue(25)：4658-4660,3.DOI:10.3969/j.issn.1673-8225.2011.25.024
聚对苯二甲酸乙二醇酯表面接枝改性及其血液相容性的研究进展
Research progress of surface grafting polymerization and blood compatibility of polyethylene terephthalate
张宝元 1赵梨 1张娟 1陆群 1吴坚1
作者信息
- 1. 西南交通大学生命科学与工程学院,四川省成都市,610031
- 折叠
摘要
Abstract
BACKGROUND: Polyethylene terephthalate is a kind of polyester materials with excellent mechanical properties and chemical inertia, but the surface must be modified and their blood compatibility should be improved because of poor blood compatibility of polymeric materials.OBJECTIVE: Based on clotting mechanism, this study introduced surface grafting modification method of polyethylene terephthalate and the blood compatibility after the modification.METHODS: A computer-based online search of PubMed, SDOS and CNKI database from 1990 to 2009 was performed for articles about the mechanism of blood coagulation, type of anticoagulant drugs and their effects on blood coagulation, as well as the polyethylene terephthalate properties, surface grafting method and blood compatibility evaluation.RESULTS AND CONCLUSION: The molecules grafted on the surface just modify a sort of specific properties of materials, which is the limitation of the current approaches of surface grafting polymerization of polyethylene terephthalate. Yet the environment where biomaterials exist in vivo is extremely complex, it is hard to fundamentally improve the blood compatibility of materials through modifying specific properties of materials solely. Then, through inducing the vascular endothelial cell that has physiological activity to adhere and grow by grafting specific molecules from the point of view of bionics, a novel surface which is similar to the model of natural vessel wall can be constructed that will must become the next major direction of promoting the blood compatibility of biomaterials.关键词
聚对苯二甲酸乙二醇酯/生物材料/血液相容性/改性/表面接枝分类
医药卫生引用本文复制引用
张宝元,赵梨,张娟,陆群,吴坚..聚对苯二甲酸乙二醇酯表面接枝改性及其血液相容性的研究进展[J].中国组织工程研究与临床康复,2011,15(25):4658-4660,3.
