中国组织工程研究与临床康复2011，Vol.15Issue(25)：4587-4590,4.DOI:10.3969/j.issn.1673-8225.2011.25.008
多孔聚乙烯醇/明胶软骨组织工程支架复合材料的制备及其生物相容性
Preparation and biocompatibility evaluation of composite scaffold material of polyvinyl alcohol/gelatin
郭涛 1韩志 2杨天府 3李玉宝 4苑天红 5肖杰 1陈艺新1
作者信息
- 1. 贵阳市第四人民医院骨科,贵州省贵阳市,550002
- 2. 贵阳中医学院,贵州省贵阳市,550002
- 3. 四川大学华西医院骨科,四川省成都市,610041
- 4. 四川大学分析测试中心,四川省成都市,610041
- 5. 贵阳医学院,贵州省贵阳市,550004
- 折叠
摘要
Abstract
BACKGROUND: The tissue engineered scaffolds prepared with gelatin as base have good biocompatibility and biodegradability,but low mechanical properties and difficulty to control degradation rate are their shortcomings.OBJECTIVE: To prepare a new type of composite scaffold material of polyvinyl alcohol/gelatin and to evaluate the biocompatibility of composite scaffold.METHODS: New type composite materials (polyvinyl alcohol/gelatin) were prepared by foaming method. The pore size and porosity, IR spectroscopy, mechanical performance and biocompatibility were detected by using scanning electron microscope,mechanical test and subcutaneous implantation test.RESULTS AND CONCLUSION: Composite materials (polyvinyl alcohol/gelatin) were three-dimensional porous structure. The pore size was even, and the porosity was 61.8％. The water content rate of the composite materials was 44.6％. The tensile strength was (5.01±0.03) MPa, and the compressive strength was (1.47±0.36) MPa. The new type composite materials have been proved to have good biocompatibility and biomechanical properties.关键词
多孔聚乙烯醇/明胶/软骨组织工程/支架/复合材料分类
基础医学引用本文复制引用
郭涛,韩志,杨天府,李玉宝,苑天红,肖杰,陈艺新..多孔聚乙烯醇/明胶软骨组织工程支架复合材料的制备及其生物相容性[J].中国组织工程研究与临床康复,2011,15(25):4587-4590,4.
