安徽农业科学2011，Vol.39Issue(11)：6397-6398,2.
连翘叶水提取物对小鼠急性毒性和微核试验
Acute Toxicity Test and Micronucleus Test of Forsythia Suspensa Leavies in Mice
艾霞 1董雪婷 1王丽洁 1韩雪 1罗春蕊1
作者信息
摘要
Abstract
[ Objective ] The study aimed to investigate the acute toxicity and mutagenicity of Forsythia suspensa leavies in mice. [ Method ] To study the the acute toxicity of Forsythia suspensa leavies, the largest amount was administrated to the mice by stomach feeding. Within 7 d observation, the mice were continuously observed. And at the end of the experiment, mice were sacrificed for autopsy. The hematological indexes and bio-chemical indexes of blood were detected. The micronuclear tests in polychromatophil cells were performed. [ Result] There was no significant difference on the acute toxicity test, behavioral characteristics, weight, pathological anatomy of visceral organs, hematological indexes and biochemical indexes between the experimental groups and the control group. The maximum amount of observation was 60 000 mg/kg. Micronucleus test was the negative reaction. [ Conclusion] The Forsythia suspensa leavies belonged to the non-toxic substance and had no mutagenicity in mice according to the test. The Forsythia suspensa leavies were safe in veterinary clinical application.关键词
连翘叶水提取物/急性毒性试验/最大给药量/微核试验Key words
Forsythia suspensa leavies/ The acute toxicity test/ The maximum amount of administration/ Micronucleus test分类
农业科技引用本文复制引用
艾霞,董雪婷,王丽洁,韩雪,罗春蕊..连翘叶水提取物对小鼠急性毒性和微核试验[J].安徽农业科学,2011,39(11):6397-6398,2.
