中国组织工程研究与临床康复2011，Vol.15Issue(25)：4719-4722,4.DOI:10.3969/j.issn.1673-8225.2011.25.039
组织工程支架材料在脊髓损伤修复中的应用
Application of tissue engineering scaffold materials in repair of spinal cord injury
摘要
Abstract
BACKGROUND: Spinal cord injury (SCI) often leads to the continuous loss of cells and tissues initially. Tissue engineering scaffolds can simulate the physiological state of the extracellular matrix, which is conducive to cell adhesion, migration, proliferation and differentiation.OBJECTIVE: to summarize the progress of tissue engineering scaffold materials combined with cells and (or) cytokines repairing SCI.METHODS: The articles related to tissue engineering scaffold materials repairing SCI from PubMed database, Ovid Medline database and CBM database between October 2000 and October 2010 were retrieved by computer. RESULTS AND CONCLUSION: Tissue engineering materials for repair of SCI need three elements: seed cells, tissue engineering scaffold, and cytokines. Tissue engineering scaffold plays a bridging role in broken ends of fractured bone of SCI;however, the seed cells and (or) cytokines can promote the growth and migration of neural axon. The materials that can be used for tissue engineering scaffold were divided into natural materials and synthetic materials, including collagen, chitosan,agarose/alginate, polylactic acid, fibronectin, polyglycolic acid/polylactic acid, poly-β hydroxybutyrate, etc. Animal experiments have obtained some achievements. Tissue engineering scaffold materials combined with cell transplantation have a better effect on repairing SCI. However, there is no research addressing tissue engineering scaffold materials repairing SCI currently.关键词
脊髓损伤/组织工程支架/组织工程/种子细胞/生物材料分类
医药卫生引用本文复制引用
王新宏,沈忆新,范志海,张峰..组织工程支架材料在脊髓损伤修复中的应用[J].中国组织工程研究与临床康复,2011,15(25):4719-4722,4.基金项目
江苏省卫生厅面上科研课题(H200920)资助. （H200920）
