中国组织工程研究与临床康复2011，Vol.15Issue(25)：4739-4742,4.DOI:10.3969/j.issn.1673-8225.2011.25.044
再生氧化纤维素在严重骨质疏松体外循环手术胸骨止血中的作用
Role of oxidized regenerated cellulose in the hemostasis of severe sternal osteoporosis during cardiopulmonary bypass
摘要
Abstract
BACKGROUND: Patients with serious osteoporosis have more bleeding volume than those without osteoporosis during cardiac surgery with cardiopulmonary bypass.OBJECTIVE: To study the efficacy of oxidized regenerated cellulose on reducing post-cardiopulmonary bypass sternal bleeding and preventing sternal infection in patients with severe osteoporosis．METHODS: Eighty-four cases of severe osteoporosis undergoing open heart surgery were randomly divided into oxidized regenerated cellulose group and control group. The sternal wound and bone marrow cavity of the oxidized regenerated cellulose group was filled with oxidized regenerated cellulose, and that of the control group was with medical bone wax. Drainage volume at the first postoperative day, total drainage volume, time of draining tube, blood transfusion volume, suture removal time,duration of persistent fever, average hospital staying, postoperative sternal wound healing were recorded and observed, and all the patients were follow-up for 6 months.RESULTS AND CONCLUSION: The comparison between two groups in the drainage volume at the first postoperative day, the total drainage volume, time of draining tube, the volume of blood transfusion and average hospital staying was significantly different (P ＜ 0.05). During the follow-up, there was no case of discharging the foreign body from sternal wound in the oxidized regenerated cellulose group and 3 cases of discharging bone wax in the control group. Oxidized regenerated cellulose can be used in reducing bleeding and preventing sternal infection in patients with severe sternal osteoporosis after cardiopulmonary bypass. The short- and long-term efficacy is reliable.关键词
再生氧化纤维素/骨质疏松/胸骨/止血/体外循环/骨蜡分类
医药卫生引用本文复制引用
王春,谷天祥,喻磊,刘波,卢春茂..再生氧化纤维素在严重骨质疏松体外循环手术胸骨止血中的作用[J].中国组织工程研究与临床康复,2011,15(25):4739-4742,4.基金项目
辽宁省教育厅基金项目(2004C050)《微创非体外循环不停跳冠状动脉搭桥手术临床及应用基础研究》 （2004C050）
辽宁省科学技术计划项目(2006401013-2)《心脏静脉原位动脉化治疗冠心病弥漫性狭窄及全程闭塞的临床基础研究》. （2006401013-2）
