肿瘤防治研究2011，Vol.38Issue(3)：278-280,285,4.DOI:10.3971/j.issn.1000-8578.2011.03.010
原发性肝细胞癌中P-gp,TopoⅡα和P53的表达及意义
Fxpression and Implication of P-gp,TopoⅡα and P53 in Primary Hepatocellular Carcinoma
摘要
Abstract
Objective To explore the expression of P-glycoprotein (P-gp), topoisomerase Ⅱ alpha (Topo Ⅱ α), P53 in primary hepatocellular carcinoma (PHC) and their correlations with clinical characteristics.Methods The expressions of P-gp, TopoⅡ α and P53 were detected by means of SP immunohistochemical technique in 135 cases of PHC. Results The positive rates of P-gp, Topo Ⅱ α and P53 were 80. 74％(109/135), 46. 67％ (63/135), 33. 33％ (45/135) respectively. The positive rate of P-gp was higher than that of TopoⅡ α or P53 (P = 0. 000). The positive rate of Topo Ⅱ tα was higher than that of P53(P＜0. 05). The expression of P-gp was related to age, tumor differentiation and tumor size. The expressions of P-gp and Topo Ⅱ α were higher in cases with AFP-elevated than those of AFP-normal (P＜0. 05). The expressions of P-gp and P53 were higher in cases with AST-elevated than those of AST-normal (P＜0. 05). The expressions of Topo Ⅱ α and P53 weren't related to age, tumor differentiation and tumor size (P＞0. 05). The co-expression rate of multidrug resistant genes was 51.85％ (70/135). The co-expression rate was higher than individual expression rate (34. 07％, x2 = 8. 706, P＜0. 01). Conclusion The multidrug resistance of PHC is affected by various multidrug resistance genes. There is synergistic effect between single and multiple genes, co-expression of multiple genes mainly. It is important that detection of their expressions may guide the clinical use of drugs and predicate chemotherapy effects.关键词
原发性肝细胞癌/多药耐药/P-糖蛋白/拓扑异构酶Ⅱα/P53分类
医药卫生引用本文复制引用
陈漫霞,姚振江,陈思东,王漫云,许雅,蔡旭玲..原发性肝细胞癌中P-gp,TopoⅡα和P53的表达及意义[J].肿瘤防治研究,2011,38(3):278-280,285,4.基金项目
广东省自然科学基金资助项目(07117591) （07117591）
