肿瘤防治研究2011，Vol.38Issue(3)：308-311,4.DOI:10.3971/j.issn.1000-8578.2011.03.018
IMRT联合锥形束CT技术治疗颅内危险区肿瘤病灶
Application of IMRT Combined with Cone-beam Computed Tomography in Treatment of Intracranial Tumor
摘要
Abstract
Objective To evaluate the interfractional three-dimensional (3D) setup error and propose optimum margin of planning target volume (PTV) in radiotherapy for intracranial tumor at risk of using intensity modulated radiotherapy (IMRT) guided with cone-beam computed tomography (CBCT). Methods Thirty-six patients received radiotherapy of IMRT imaging-guided with megavolt MVision CBCT scans equipped in ONCOR Linear Accelerator. The initial five fractional CBCT volume-imaging and data obtained by CBCT scans after initial setup and after re-positioning were dimensionally matched with planned CT images. Results The interfractional setup errors on X, Y and Z axes were (2. 22 ± 1.37) mm, (2. 62 ± 1. 50) mm and (2. 77 ± 1.34) mm, respectively, for 36 intracranial tumors. Comparing with the precorrection position, the post-correction setup errors decreased significantly on all three axes (P＜0. 05),whereas there were no statistically significant difference in five fractional setup errors (P＞0. 05). While without correction of CBCT setup errors, PTV margin in three dimension were Lat(cm)-X: 2. 94 mm,Long(cm)-Y:3. 31mm,Vert(cm)-Z:3. 52 mm. While with correction of CBCT setup errors, PTV margin in three dimension were,Lat (cm)-X: 1.00 mm, Long (cm)-Y: 1.19 mm,Vert (cm)-Z: 1.68 mm. Conclusion The set-up margins were ＜4 mm in all directions. Measurement and correction of interfractional setup errors and PTV margins before fractional radiotherapy using megavolt MVision CBCT could help to improve the precision of IMRT radiotherapy for intracranial tumors.关键词
调强放射治疗/锥形束CT/摆位误差/图像引导/颅内肿瘤分类
医药卫生引用本文复制引用
马洁韬,韩琤波,贾明轩,张旭,邹华伟..IMRT联合锥形束CT技术治疗颅内危险区肿瘤病灶[J].肿瘤防治研究,2011,38(3):308-311,4.基金项目
国家自然科学基金资助项目(30700979) （30700979）
辽宁省科技攻关课题(2006225007-6) （2006225007-6）
