医药导报2011，Vol.30Issue(6)：751-753,3.DOI:10.3870/yydb.2011.06.019
氯氮平治疗精神分裂症时引发糖尿病的前期临床特点
Early-phase of Clinical Phenomenon of Diabetes Caused by Clozapine in the Treatment of Schizophrenia
岳卫清 1姚明荣 1曹明 1袁天懿 1查显友 1夏江明1
作者信息
- 1. 浙江省嘉兴市康慈医院精神科,314500
- 折叠
摘要
Abstract
Objective To study the clinical features before development of diabetes caused by clozapine. Methods The clinical open surveys were used in 82 patients with schizophrenics who were given with clozapine only. The fasting plasma glucose,2 hours postprandial blood glucose, triglyceride( TG ), blood cholesterol( TC ), body weight, height, body mass index ( BMI ) were tested every month. The international physical activity questionnaire short form( IPAQ-SF ) was used to assess these patients' physical activity level. After one year follow-up ,22 patients were diagnosed as diabetes. The diagnosed diabetes or the end of study was regarded as baseline. the investigated indicators were analyzed. Results Triglyceride and BMI in both diabetes groups were 2.95 -3.94,1.93 -2.31 mol · L-1 and 24.78 -26.30,22.91-23.67, respectively( P＜0.01 ), physical activity of the diabetes group was lower than that of the non-diabetes group( P＜0.01 ). Conclusion Triglyceride, BMI and physical activity level were abnormal 1 a before diabetes caused by clozapine.关键词
氯氮平/精神分裂症/糖尿病/临床特点分类
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岳卫清,姚明荣,曹明,袁天懿,查显友,夏江明..氯氮平治疗精神分裂症时引发糖尿病的前期临床特点[J].医药导报,2011,30(6):751-753,3.
