实用医学杂志2011，Vol.27Issue(10)：1757-1759,3.DOI:10.3969/j.issn.1006-5725.2011.10.018
溃疡性结肠炎组织中5-LOX、PPARγ和NF-κB P65的表达及意义
Expression and significance of 5-LOX,PPARγ,and NF-κB P65 in colon mucosa of ulcerative colitis
摘要
Abstract
Objective To investigate the expression and role of 5-Lipoxygenase (5-LOX ) ,Peroxisome proliferater-activated receptor γ (PPARγ)and Nuclear factor kappa B P65 (NF-κB P65) in colon mucosa of ulcerative colitis (UC)and to analyze their correlations. Methods Immunohistochemical technology was applied to detect the expression of 5-LOX, PPARγ and NF-κB P65 protein in colonic mucosa of 32 UC patients and 26 healthy controls. Results The expression of 5-LOX and NF-κB P65 protein in UC patients were significantly increased than that in healthy controls (P ＜ 0.05). The expression of PPARγ protein in UC patients was significantly decreased than that in healthy controls (P＜0.05). 5-LOX and NF-κB P65 immunoreactivity was significantly associated with pathologic gracling of UC. There were negative relation between the expression of PPARγ and pathologic grading. The expression of 5-LOX exhibited a positive correlation to NF-κB P65 protein .The expression of 5-LOX and NF-KB P65 protein exhibited a negative correlation to PPARγ. Conclusion 5-LOX may affect the inflammation of UC through PPARγ-NF-κB p65 signaling pathway and may be treated as a target site.关键词
结肠炎,溃疡性/5-脂氧合酶/过氧化物酶增殖物激活受体γ/核转录因子κB引用本文复制引用
苗新普,欧阳钦,韦红,黄咏东..溃疡性结肠炎组织中5-LOX、PPARγ和NF-κB P65的表达及意义[J].实用医学杂志,2011,27(10):1757-1759,3.基金项目
海南省卫生厅资助课题(编号:琼卫2009-008) （编号:琼卫2009-008）
