实用医学杂志2011，Vol.27Issue(10)：1765-1767,3.DOI:10.3969/j.issn.1006-5725.2011.10.021
经肺动脉持续灌注低温含氧血及乌司他丁对肺的保护作用
Direct perfusion with hypothermic oxygenated blood mixed with ulinastatin through pulmonary artery to protect pulmonary function during cardiopulmonary bypass
陈宝俊 1孙明 1邵峻 1王东进1
作者信息
- 1. 210008,南京大学医学院附属南京鼓楼医院心胸外科
- 折叠
摘要
Abstract
Objective To observe the influence of continuous perfusion of pulmonary artery with hypothermic oxygenated blood mixed with ulinastatin on the pulmonary function. Methods One hundred and thirty patients with heart valves disease were divided into 2 groups :protective group and control group. In control group,the operation was performed in a routine way,while in protective group, pulmonary artery was infused with hypothernic oxygenated blood mixed with ulinastatin. The tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),interleukin-8 (IL-8) were assessed at different time points: anesthetic induction, the end of CPB,6 h after CPB, 12 hr after CPB, and 24 hr after CPB. The time of mechanical ventilation was obtained as well. Results In both groups, compared with the baseline values, plasma levels of TNF-α、IL-6、IL-8 were gradually increased after the beginning of CPB and still maintained a high level at 24 hours after CPB (P ＜ 0.05). Comparing to the control group,the increasing degree of TNF-α、IL-6、IL-8 were significantly lower than that in protective group (P ＜0.01 ).Conclusion Continuous perfusion of pulmonary artery with hypothermic oxygenated blood mixed with ulinastatin can alleviate the lung injury after CPB.关键词
体外循环/乌司他丁/肺损伤引用本文复制引用
陈宝俊,孙明,邵峻,王东进..经肺动脉持续灌注低温含氧血及乌司他丁对肺的保护作用[J].实用医学杂志,2011,27(10):1765-1767,3.
