原子能科学技术2011，Vol.45Issue(3)：369-373,5.
高分辨率小动物SPECT成像系统的设计与性能评估
Design and Performance Evaluation of High-Resolution Small Animal SPECT System
摘要
Abstract
A high-resolution and low-cost small animal single photon emission computed tomography (SPECT) system was designed based on a clinical scanner and a pinhole collimator. Optimal design schemes of a single-pinhole collimator and a seven-pinhole one were proposed, in terms of achieving the best trade-off of field of view size, spatial resolution and sensitivity. System performances of the two design schemes were compared by evaluating the average spatial resolution and sensitivity over the full field of view,and the seven-pinhole collimator design demonstrated improved resolution and better sensitivity. Monte Carlo simulation studies validate that ultra-high 0. 5 mm spatial resolution can be achieved with the proposed seven-pinhole design, which is cost-effective comparing to the existing animal SPECT systems equipped with dedicated detector.关键词
单光子发射断层成像/小动物成像/针孔准直器/空间分辨率/探测效率/蒙特卡罗模拟分类
医药卫生引用本文复制引用
戴甜甜,刘亚强,马天予,夏彦,王石,魏清阳,金永杰..高分辨率小动物SPECT成像系统的设计与性能评估[J].原子能科学技术,2011,45(3):369-373,5.基金项目
教育部博士点基金资助项目(200800031071) （200800031071）
国家自然科学基金资助项目(10975086) （10975086）
国家863计划资助项目(2006 AA020802 ) （2006 AA020802 ）
