分析测试学报2011，Vol.30Issue(3)：298-301,306,5.DOI:10.3969/j.issn1004-4957.2011.03.013
2,6-二-O-乙氧乙基-3-O-三氟乙酰基-β-环糊精气相色谱手性固定相的制备及应用
Preparation of Gas Chromatography Chiral Stationary Phase Heptakis(2, 6-di-O-ethoxyethyl-3-O-trifluoroacetyl)-β-cyclodextrin and Its Application
尹明明 1朱小波 2刘勇良 1钟江春 3陈福良1
作者信息
- 1. 中国农业科学院植物保护研究所,农药化学与应用重点开放实验室,北京,100193
- 2. 中国民用航空局第二研究所,四川,成都,610041
- 3. 中国农业大学理学院,北京,100193
- 折叠
摘要
Abstract
A new cyclodextrin derivative heptakis ( 2, 6-di-O-ethoxyethyl-3-O-trifluoroacetyl) -β-cyclo-dextrin was synthesized by substituting the 2, 6-OH groups of cyclodextrin derivative with ethoxyethyl groups and the 3-OH group with trifluoroacetyl group, and used to coat capillary column of gas chromatography by static method. The chromatographic properties and separation abilities of the capillary column were studied. The results showed that the stationary phase possessed good separation efficiencies to Grob test mixture, disubstituted benzene isomers( such as chlorotoluene, nitrotoluene and bromotoluene) and ten kinds of chiral compounds (such as a-substituted propionate, 1-( 2'-nitrophenyl) -ethanol, α-methyl-4-chlorobenzyl cyanide, 2-methyl-4-oxo-3-prop-2-ynyl-cyclopent-2-enyl acetate). Among the test compounds, the separation ability of chiral stationary phase for 2-methylsulfo-nylpropionate was the best, the separation efficiency of methyl ester derivatives of chiral stationary phase for α-substituted propionic was better than that of ethyl ester derivatives, and methyl ester and ethyl ester derivatives of α-hydroxypropionic were better than that of α-halogenpropionic.关键词
环糊精衍生物/毛细管气相色谱/手性固定相Key words
cyclodextrin derivatives/ capillary gas chromatography/ chiral stationary phase分类
化学化工引用本文复制引用
尹明明,朱小波,刘勇良,钟江春,陈福良..2,6-二-O-乙氧乙基-3-O-三氟乙酰基-β-环糊精气相色谱手性固定相的制备及应用[J].分析测试学报,2011,30(3):298-301,306,5.
