内科理论与实践2011，Vol.6Issue(2)：135-139,5.
原发性醛固酮增多症主要亚型的基因分型研究
Analysis of polymorphism of CYP11B2 gene in major subtypes of primary hyperaldosteronism
摘要
Abstract
Objective To investigate the correlation between two major subtypes of primary aldosteroism (PH),aldosterone-producing adenoma (APA) and idiopathic aldosteronism (IHA), with gene polymorphism of CYP11B2.Methods One hundred and twenty PH patients and 200 essential hypertension (EH) patients admitted from August 2005 to March 2007 were enrolled. The 120 PH patients were categorized into APA (57 patients) and IHA (63 patients) groups by adrenal vein sampling (AVS) test. The correlation between polymorphisms of CYP11B2 T(-344)C, Lys173 Arg(K173R) and intron2 (Rs 10086846, Rs7461740)determined by restriction fragment length polymorphisms (RFLP) and real-time PCR and the three groups (EH, APA, IHA) was analyzed. Results Genotype TT/KK/CT/CG had the highest frequency in 1HA (IHA 29.5％ vs APA 6.5％ vs EH 16.1％ ,P=0.026). And the low renin EH patients with genotype TT/KK/CT/CG had a trend to develop IHA more commonly. Conclusions Genotype TT/KK/CT/CG had the highest frequency in IHA.关键词
原发性醛固酮增多症/原发性高血压/基因型/醛固酮腺瘤/特发性醛固酮增多症Key words
Primary aldosteronism/ Essential hypertension/ Genotype/ Aldosterone-producing adenoma/Idiopathic aldosteronism分类
医药卫生引用本文复制引用
郭瑞敏,龚艳春,郭冀珍,初少莉,朱鼎良..原发性醛固酮增多症主要亚型的基因分型研究[J].内科理论与实践,2011,6(2):135-139,5.基金项目
上海市卫生局课题(项目编号:2006041) （项目编号:2006041）
