中国药房2011，Vol.22Issue(21)：1970-1972,3.
甲磺酸倍他司汀微孔渗透泵控释片包衣处方的优化
Optimization of the Coating Prescription of Betahistine Mesilate Controlled Porosity Osmotic Pump Tablets
周苏 1冯晶 1郭斌2
作者信息
- 1. 辽宁医学院,锦州市,121001
- 2. 辽宁医学院附属第一医院,锦州市,121000
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Betahistine mesilate controlled porosity osmotic pump tablets, and to optimize the coating prescription.METHODS: Main influencing factors of drug release of Betahistine mesilate controlled porosity osmotic pump tablets were investigated with single factor experiment.The coating prescription of Betahistine mesilate controlled porosity osmotic pump tablets was optimized by orthogonal test using amount of PEG and DBP as factors and with drug release indicator L as index.RESULTS:Similar factor was less than 50 which indicated that the amount of PEG, DBP and coating level influence the in vitro drug release significantly.The optimized coating prescription was PEG 30％, DBP 20％ and the increases of coating material 4％.The drug release indicators of 3 batches of samples in validation test were 13.99, 11.15 and 8.37.Accumulative drug release rate was more than 90％ within 12 h, and drug release model showed zero-level drug release characteristics.CONCLUSION: Betahistine mesilate controlled porosity osmotic pump tablets with optimized prescription can achieve constant complete release in 12 hours.关键词
甲磺酸倍他司汀/微孔渗透泵控释片/包衣处方/正交设计/优化Key words
Betahistine mesilate/ Controlled porosity osmotic pump tablets/ Coating prescription/ Orthogonal design/ Optimization分类
医药卫生引用本文复制引用
周苏,冯晶,郭斌..甲磺酸倍他司汀微孔渗透泵控释片包衣处方的优化[J].中国药房,2011,22(21):1970-1972,3.
