中国药房2011，Vol.22Issue(21)：1979-1981,3.
氯霉素眼用温敏原位凝胶的制备及其兔眼刺激性研究
Preparation and Eye Irritation on Rabbits of Chloramphenicol Thermosensitive In-situ Gels for Ophthalmic Use
郝吉福 1李学桐 2张翠玲 2王建筑 1郭丰广 1李菲1
作者信息
- 1. 泰山医学院药学院,泰安市,271000
- 2. 山东泰安荣军医院,泰安市,271000
- 折叠
摘要
Abstract
OBJECTIVE: To prepare chloramphenicol thermosensitive in-situ gels for ophthalmic use and to evaluate erosion and eye irritation character of gel in rabbit. METHODS: The thermosensitive gels were prepared by cold-solving method, and the content of chloramphenicol was determined by HPLC. The drug release of the formulation was investigated with a membrane-less dissolution model and drug release mechanism was explored. Eye irritation experiments were performed on rabbit by eye instillation for 7 days. RESULTS: Prepared gels were liquid at room temperature and turned into semi-solid gels at body temperature. The in vitro release experiment showed that the release of chloramphenicol from poloxamer gels followed Hixon-Crowell kinetics while the erodible rates of gel accorded with zero-order model. The drug release mechanism included drug diffusion and gel erosion. The irritation score of gels was lower than 3 after administration. R suggested that the thermosensitive in-situ gel containing chloramphenicol was nonirritant. CONCLUSION: Prepared formulation meets the demands of thermosensitive in-situ gel for ophthalmic use.关键词
氯霉素/眼用温敏原位凝胶/制备/凝胶溶蚀/体外释放/家兔/眼刺激性Key words
Chloramphenicol/ Thermosensitive in-situ gel for ophthalmic use/ Preparation/ Gel erosion/ In vitro release/ Rabbit/ Eye irritation分类
医药卫生引用本文复制引用
郝吉福,李学桐,张翠玲,王建筑,郭丰广,李菲..氯霉素眼用温敏原位凝胶的制备及其兔眼刺激性研究[J].中国药房,2011,22(21):1979-1981,3.
