中国药房2011，Vol.22Issue(21)：1985-1987,3.
复方洛美沙星缓释凝胶滴耳剂的制备及其质量控制
Preparation and Quality Control of Compound Lomefloxacin Sustained-release Gel Eardrops
谢燕贤 1陈丽娜 2温中明 3李东4
作者信息
- 1. 深圳市宝安区石岩人民医院,深圳市,518108
- 2. 深圳市宝安区人民医院,深圳市,518101
- 3. 深圳市光明新区公明人民医院,深圳市,518106
- 4. 深圳市人民医院,深圳市 518020
- 折叠
摘要
Abstract
OBJECTIVE: To prepare Compound lomefloxacin sustained-release gel eardrops and to establish the quality control methods. METHODS: The eardrops was prepared by taking carbomer-940 as a base in the gel. The contents of lomefioxacin hydrochloride and dexamethasone were determined by HPLC, and in vitro drug release and stability of gels were investigated. RESULTS: Prepared eardrops were well-distributed, delicate, stable with good dispersity. Accumulative release rates of lomefloxacin hydrochloride and dexamethasone were both lower than 30％ at 1 h, 53％ and 52％ at 36 h, more than 80 ％ at 72 h. Results of stability tests indicated 2 kinds of components were unstable under sunlight. CONCLUSION: The preparation of eardrops is simple, and the gel is controllable in quality with sustained-release effect. Prepared eardrops should be kept in dark place.关键词
复方洛美沙星缓释凝胶滴耳剂/制备/质量控制/地塞米松/高效液相色谱法/稳定性Key words
Compound lomefloxacin sustained-release gel eardrops/ Preparation/ Quality control/ Dexamethasone/ HPLC/ Stability分类
医药卫生引用本文复制引用
谢燕贤,陈丽娜,温中明,李东..复方洛美沙星缓释凝胶滴耳剂的制备及其质量控制[J].中国药房,2011,22(21):1985-1987,3.
