国际医药卫生导报2011，Vol.17Issue(11)：1366-1368,3.DOI:10.3760/cma.j.issn.1007-1245.2011.11.030
喹硫平治疗老年痴呆患者精神行为症状的临床观察
Quetiapine for the behavioral and psychological symptoms in senile dementia
张瑜良 1刁秋莺 1张恒铭1
作者信息
- 1. 514089,梅州市第三人民医院精神一科
- 折叠
摘要
Abstract
Objective To explore the efficacy and safety of quetiapine and perphenazine in the treatment of Alzheimer's disease. Metbods 52 patients were randomly assigned to receive quetiapine of SO - 400mg daily ( 26 patients, study group), or perphenazine of 6-16mg daily ( 26 patients, control group )for 8 weeks. The efficacy and safety of the two therapies was compared between the two groups by using the Mini-mental State Examination ( MMSE ), Sandoz Clincal Assessment Geriatric ( SCAG ), and Treatment Emergent Symptom Scale (TESS ) 8 weeks after treatment. Results At the completion of treatment, the scores on MMSE were significantly higher ( P< 0.01 ), and those on SCAG were significantly lower in both groups ( P< 0.01 or P< 0.05 ), as compared with the baseline scores. The rate of adverse reactions was significantly lower in the study group than in the control group ( 30.8% vs. 46.2%, P< 0.05 ) Conclusions Quetiapine has a better efficacy in the treatment of Alzheimer's disease and has fewer adverse reactions. It is suitable for clinical use.关键词
喹硫平/老年痴呆/精神行为症状Key words
Quetiapine/Senile dementia/Psychological and behavioral symptoms引用本文复制引用
张瑜良,刁秋莺,张恒铭..喹硫平治疗老年痴呆患者精神行为症状的临床观察[J].国际医药卫生导报,2011,17(11):1366-1368,3.
