辐射防护2011，Vol.31Issue(2)：83-87,5.
急性放射性肺损伤肺组织CD36表达及意义
Expression and Significance of CD36 on Acute Radiation-induced Lung Injury
摘要
Abstract
To investigate the pathology of acute radiation- induced lung injury and expression and significance of thrombospondin-1 (TSP-1) receptor CD36 during different phases in rats, forty Wistar rats were randomly divided into control group (C) and radiation group (R). Both groups were radiated with 6WV X ray linear accelerator at dose of 15 Gy thoracically, 2 Gy/min, with SSD 1 m and radiation area 4.5 cm×4.5 cm. The pathological change of lung tissue and the expression of CD36 were detected with HE, Masson and immunohistochemistry staining, respectively. Result HE and Masson staining showed that only one week after radiation, the alveolar spaces had exudative inflammatory cells,following interstitial edema, and at 4 and 8 weeks, alveolar spaces shrank, even its structure was destroyed with local consol, and pulmonary interstitium appeared collagen fibers. The expression of CD36 was significantly higher in radiation group at all phases (p＜0.01) . The expression of CD36 increased significantly in radiation-induced lung injuy. CD36 participated in the process of radation-induced lung injury, and inhibition of CD36 expression may have preventive effect on radation-induced lung injury.关键词
肺癌/放射性肺损伤/CD36Key words
Lung Cancer/ Radiation-induced Lung Injury/ CD36分类
医药卫生引用本文复制引用
曹丽艳,于洪,赵俊华,赵玉霞,门桐林,赵娜,刘丹,白露..急性放射性肺损伤肺组织CD36表达及意义[J].辐射防护,2011,31(2):83-87,5.基金项目
沈阳市社会事业科技创新项目资助(1081269-9-00). （1081269-9-00）
