广西医学2011，Vol.33Issue(5)：516-519,4.
人类β-防御素2在口腔扁平苔藓病损中表达的研究
Study of the Expressions of Human β-defensin-2 in the Oral Epithelium of Patients with Oral Lichen Planus
摘要
Abstract
Objective To investigate the expressions of human β-defensin-2( hBD-2 )in oral epithelium in patients with oral lichen planus( OLP ) , and explain the pathomechanism of hBD-2 in OLP and inflammatory response of epithelium. Methods Oral mucous tissue samples from 25 OLP patients and 7 health controls were included in this study. ImmunohistochemistrY( IHC )and reverse transcription-polymerase( RT-PCR )were used to evaluate the expression of hBD-2 separately. Results Positive stains of hBD-2 were observed in all the samples by IHC method. The reaction intensity in OLP group was strong,while in health controls it showed weak signal,which showed statistical difference ( P ＜0. 05 ). By RT-PCR,hBD-2 were expressed in cDNA electrophoresis strips both in health controls and patients. The expressions levels of hBD-2 mRNA in OLP patients were significantly higher than those of health controls( P ＜0. 05 ).Conclusion The small amount of expressions of hBD-2 on normal oral mucosa,which suggests that it play a role in maintaining the health of oral mucosa as a part of innate immunity. The up-regulating expression of hBD-2 under inflammation station in OLP may participate in the immunity course of OLP.关键词
口腔扁平苔藓/人类β-防御素2/唾液/上皮分类
医药卫生引用本文复制引用
肖丽婷,邹杰,陶人川,杨亦萍,曾启新..人类β-防御素2在口腔扁平苔藓病损中表达的研究[J].广西医学,2011,33(5):516-519,4.基金项目
国家自然科学基金资助项目(30860313) （30860313）
广西科学基金资助项目(0639619) （0639619）
