北京大学学报（医学版）2011，Vol.43Issue(2)：250-254,5.DOI:10.3969/j.issn.1671-167X.2011.02.017
血清生长分化因子-15与急性冠状动脉综合征的相关性分析
Correlation between levels of serum growth differentiation factor-15 and acute coronary syndrome
摘要
Abstract
Objective : To explore the association between the levels of serum growth differentiation factor-15 ( GDF-15 ) and acute coronary syndrome ( ACS) in patients undergoing coronary angiography ( CAG) . Methods: In this prospective study, 120 candidates (30 healthy controls and 90 patients with ACS ) admitted to our hospital from March 2006 to April 2008 were included. The patients with ACS were divided into 3 groups : ( 1) Group AMI-emergency ( AMI-E) , including 30 patients with acute myocardial infarction ( AMI) who underwent CAG within 12 hours of the onset of symptoms. (2) Group AMI 7 - 14 d, including 30 patients with AMI who underwent CAG within 7 - 14 days of the onset of symptoms. (3) Group UAP including 30 patients with unstable angina pectoris. The serum level of GDF-15 was determined by ELISA. Results: The level of GDF-15 for group ACS was ( 649.0 ± 224. 21) ng/L, which was significantly higher than that of control group[ (537. 2 ±262. 9) ng/L,P ＜0. 01 ] . The level of serum GDF-15 significantly increased in group AMI-E [ (801.6 ±218.4) ng/L ] compared with group AMI 7 - 14 d[ ( 656. 2 ± 252. 4) ng/L,P = 0. 042 ,95％ CI 1. 001 - 1. 061 ] , group UAP [ (586. 9 ± 225. 6) ng/L,P = 0. 001 , 95％ CI 0. 809 - 0. 950 ] and control group(P ＜ 0. 05 ,95％ CI 1. 000 - 1. 012) after being adjusted for relevant covariates. The elevated level of GDF-15 was related to biomarkers, such as white blood cells count( WBC . r2 = 0. 276 ,P = 0. 002 ) , lactate dehyerogenase ( LDH , r2 = 0. 288 ,P = 0. 004 ) , creatine kinase 2( CK-MB ,r2 = 0. 350,P ＜0. 001 ) and troponin T( TnT, r2 =0. 344 ,P = 0. 001 ) . Conclusion : GDF-15 protein expression increases in ACS, and the level of GDF-15 rapidly increases and remains elevated in the early period of acute myocardial infarction. The elevated level of GDF-15 is related to biomarkers, such as WBC, LDH, CK-MB, and TnT. GDF-15 could be a new and independent biomarker in evaluating the patients with cardiovascular disease.关键词
生长分化因子-15/急性冠状动脉综合征/心肌梗死分类
医药卫生引用本文复制引用
郑凌冰,郭艳红,于海奕,米琳,汪宇鹏,高炜..血清生长分化因子-15与急性冠状动脉综合征的相关性分析[J].北京大学学报（医学版）,2011,43(2):250-254,5.基金项目
国家重点基础研究发展计划(2007CB512107)资助 （2007CB512107）
