北京大学学报（医学版）2011，Vol.43Issue(2)：255-258,4.DOI:10.3969/j.issn.1671-167X.2011.02.018
环氧化酶-2抑制剂对功能性鼻内镜手术后血浆及术野渗液前列腺素E2的作用
Effect of cycloxygenase 2 inhibitor on levels of prostaglandin E2 in plasma and in local infiltrated fluid after functional endoscopic sinus surgery
赵红 1王莹 1冯艺 1杨拔贤 1邢志敏 2王旻
2余力生2
作者信息
- 1. 北京大学人民医院麻醉科,北京,100044
- 2. 北京大学人民医院耳鼻喉科,北京,100044
- 折叠
摘要
Abstract
Objective : To examine the time course and clinical relevance of changes in prostaglandin E2 ( PGE2 ) to pain and outcome in surgical drainage , and circulating blood after functional endoscopic sinus surgery ( FESS) . Methods: Thirty-seven patients scheduled to undergo FESS were randomized to receive celecoxib 400 mg(n = 16) one hour before anesthesia induction and celecoxib 200 mg, q12 h for five consecutive days after surgery or nothing for patients in control group ( n = 21 ) . Surgical site drainage and venous blood were collected up to 48 hours after surgery to test PGE2 level. Plasma levels of thromboxane A2 (TXA2) and prostacyclin ( PGI2 ) were also tested for the same time course. Results: For control patients, PGE2 level was elevated in both surgical site and circulating blood, which reached a peak concentration 6 h( 177. 5 ± 142. 2 ng/L) and 48 h ( 64. 5 ±21. 4 ng/L) respectively after FESS. For patients in celecoxib group, a significant reduction of surgical drainage PGE2 ( peak level 106. 2 ± 33.4 ng/L at 6 h) and plasma PGE2( peak level 44. 7 ± 30. 2 ng/L at 48 h) was observed( P ＜0. 05 ) . Pain scores 6 h and 48 h after surgery were positively correlated with surgical drainage PGE2 level, correlation coefficient being 0. 333 ( P = 0. 044 ) and 0. 353 ( P = 0. 032) respectively. Celecoxib did not affect the ratio of plasma TXA2 to PGI2. Conclusion: Upregulation of PGE2 in surgical site after surgery was crucial in inflammatory response and postoperative pain. Cycloxygenase-2 inhibitor could significantly reduce surgical drainage and plasma PGE2 concentration.关键词
环氧化酶-2抑制剂/前列素E/外科手术/鼻疾病分类
医药卫生引用本文复制引用
赵红,王莹,冯艺,杨拔贤,邢志敏,王旻
,余力生..环氧化酶-2抑制剂对功能性鼻内镜手术后血浆及术野渗液前列腺素E2的作用[J].北京大学学报（医学版）,2011,43(2):255-258,4.
