中国神经再生研究（英文版）2011，Vol.6Issue(6)：405-411,7.DOI:10.3969/j.issn.1673-5374.2011.06.001
Neuroprotective effect of epigallocatechin-3-gallate on hemisection-induced spinal cord injury in rats
Neuroprotective effect of epigallocatechin-3-gallate on hemisection-induced spinal cord injury in rats
Fengjun Deng 1Rubing Li 1Yingbao Yang 1Dan Zhou 1Qian Wang 1Jiangping Xu1
作者信息
摘要
Abstract
Epigallocatechin-3-gallate (EGCG), a naturally occurring compound in green tea, has been widely used as an antioxidant agent. In the present study, model rats with acute spinal cord injury were intraperitoneally injected with 25, 50, and 100 mg/kg EGCG, and spinal cord ultrastructure, oxidative stress reaction, inflammatory factors, and apoptosis-associated gene expression were observed. Results showed that EGCG attenuated neuronal and axonal injury 24 hours post injury. It also decreased serum interleukin-1β, tumor necrosis factor-α, and intercellular adhesion molecule-1 release, and decreased apoptosis-associated gene expression. Furthermore, it increased the level of the superoxide anion (O2-), superoxide dismutase, and B-cell lymphoma/leukemia-2, and reduced malondialdehyde levels. Furthermore, it reduced the expression of the pro-apoptotic protein Bax. Noticeably, EGCG at the 100 mg/kg dosage exhibited similar effects as methylprednisolone sodium succinate, which has been frequently used for clinical acute spinal cord injury. The results demonstrated that EGCG can significantly inhibit inflammation, suppress oxidation, and reduce apoptosis in acute spinal cord injury.关键词
epigallocatechin-3-gallate/spinal cord injury/neuroprotective effect/oxidative stress/inflammation/apoptosisKey words
epigallocatechin-3-gallate/spinal cord injury/neuroprotective effect/oxidative stress/inflammation/apoptosis引用本文复制引用
Fengjun Deng,Rubing Li,Yingbao Yang,Dan Zhou,Qian Wang,Jiangping Xu..Neuroprotective effect of epigallocatechin-3-gallate on hemisection-induced spinal cord injury in rats[J].中国神经再生研究（英文版）,2011,6(6):405-411,7.
