解剖学杂志2011，Vol.34Issue(2)：220-222,242,4.
基底外侧杏仁核与海马CA3区参与应激所致大鼠学习记忆能力的降低
Both basolateral amygdaloid nucleus and CA3 region involves in decrement of capability in learning and memory following stress in rat
摘要
Abstract
Objective:To observe changes of capability of learning and memory and nestin/NPY-ir positive response in amygdala and hippocampus in stressed rats.Methods: The capability of learning and memory was examined in Morris water maze, and the immunohistochemical stainings of nestin/NPY-ir positive response was observed in the basolateral amygdaloid nucleus (BL) and CA3 regions with a stressed model by restrained and hung head-downed Sprague-Dawley rats.Results:(1)The escape latency and crossing times in the acute/chronic stressed (3d or 21d) and control groups were 18.27±4.20,20.02±3.02, 9.18±3.03; 4.05±1.06, 3.13±1.37 and 7.97±1.91; respectively.(2)Under a light microscope, there were morphological changes of nestin/NPY-ir positive cells in BL and CA3 regions between the stressed and control groups.(3)The integral optical densities on immunohistochemical stainings of NPY/nestin-ir positive response in the acute/chronic stressed and control groups were 1.07±0.53, 1.01±0.46 and 2.77±0.83; 1.13±0.42, 0.94±0.50 and 2.89±0.48 in BL, respectively; and 2.20±0.45, 3.41±1.20 and 11.90±0.87; 2.44±0.30, 3.95±1.24 and 9.33±0.86 in CA3 regions, respectively.Conclusion: The decrement of capability in learning and memory is involved in the damages of NPY/nestin-ir positive cells in BL and CA3 regions in acute/chronic stressed rats.关键词
应激/基底外侧杏仁核/海马/神经肽Y/巢蛋白/学习记忆Key words
stress/ basolateral amygdaloid nucleus/ hippocampus/ neuropeptide Y/ nestin/ learning and memory引用本文复制引用
范光碧,陈波,孙国刚,萧洪文,聂业..基底外侧杏仁核与海马CA3区参与应激所致大鼠学习记忆能力的降低[J].解剖学杂志,2011,34(2):220-222,242,4.基金项目
四川省卫生厅指导性科研计划项目(090194) （090194）
泸州市科技局指导性科研计划项目(090102) （090102）
