解剖学杂志2011，Vol.34Issue(2)：239-242,4.
肝门静脉高压症猪肝门静脉的结构重建
Structure remodeling of swine portal vein in portal hypertension
摘要
Abstract
Objective: To establish reliable swine portal hypertension model and explore the morphological properties of hepatic portal vein.Methods: Liver cirrhosis and portal hypertension was induced by carbon tetrachloride and fenobarbital (n = 8), 4 pigs served as the control, and the hepatic arteries were collected and serially sectioned.The tissue structure, elastic fiber, collagen fiber and smooth muscle were stained by H-E, Weigert, Aniline blue and Orange G respectively.The morphological data of hepatic arteries were obtained by the computer image analysis system.Results: The portal vein pressure of the experimental group was (4.17 ± 1.03) kpa, and that of normal group was (1.51 ± 0.79) kPa.The thickness of intima and media wall, diameter of the experimental group were significantly larger than those of the normal group (P ＜0.01).The relative content of collagenic fiber and smooth muscle, and C/E of the experimental group were also significantly larger than that of the normal group.Conclusion: In portal hypertension, the structure remodeling of the portal vein was significantly changed, and in return deteriorated the portal hypertension.关键词
猪/肝门静脉高压症/肝门静脉/几何形态/显微结构成分Key words
pig/ hepatic portal hypertension/ hepatic portal vein/ geometrical morphology/ microstructure component引用本文复制引用
贺细菊,余明华,李静,黄铁柱..肝门静脉高压症猪肝门静脉的结构重建[J].解剖学杂志,2011,34(2):239-242,4.基金项目
湖北省教育厅科学技术研究项目(D200524002和D20102103) （D200524002和D20102103）
