首页|期刊导航|中国神经再生研究（英文版）|Effects of calcium channel on 3-morpholinosydnonimine-induced rat hippocampal neuronal apoptosis
中国神经再生研究（英文版）2011，Vol.6Issue(5)：373-377,5.DOI:10.3969/j.issn.1673-5374.2011.05.009
Effects of calcium channel on 3-morpholinosydnonimine-induced rat hippocampal neuronal apoptosis
Effects of calcium channel on 3-morpholinosydnonimine-induced rat hippocampal neuronal apoptosis
摘要
Abstract
Previous studies have demonstrated that increased chloride channel activity plays a role in nitric oxide-induced neuronal apoptosis in the rat hippocampus.The present study investigated the effects of the broad-spectrum calcium channel blocker CdC12 on survival rate, percentage of apoptosis, and morphological changes in hippocampal neurons cultured in vitro, as well as the effects of calcium channels on neuronal apoptosis.The chloride channel blockers 4-acetamido-4'-isothiocyanatostilbene-2, 2'-disulfonic acid (SITS) or 4, 4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) increased the survival rate of 3-morpholinosydnonimine (SIN-1)-treated neurons and suppressed SIN-1-induced neuronal apoptosis.The calcium channel blocker CdC12 did not increase the survival rate of neurons and did not affect SIN-1-induced apoptosis or SITS- or DIDS-suppressed neuronal apoptosis.Results demonstrated that calcium channels did not significantly affect neuronal apoptosis.关键词
calcium channel/chloride channel/3-morpholinosydnonimine/rats/hippocampusKey words
calcium channel/chloride channel/3-morpholinosydnonimine/rats/hippocampus引用本文复制引用
Quanzhong Chang,Shuling Zhang,Yuanyin Zheng,Lijuan Xu,Jinbao Yin,Shining Cai..Effects of calcium channel on 3-morpholinosydnonimine-induced rat hippocampal neuronal apoptosis[J].中国神经再生研究（英文版）,2011,6(5):373-377,5.基金项目
the Science and Technology Department of Guozhou Province,No C20072127,SY20093075 （）
the Science and Technology Department of Zhuhai City,No.PC20081010 （）
