解放军医学杂志2011，Vol.36Issue(3)：237-240,4.
Salusin-β对大鼠胸主动脉血管平滑肌细胞c-fos、c-jun和增殖细胞核抗原表达的影响
Effect of Salusin-β on the expression of c-fos, c-jun and proliferating cell nuclear antigen in vascular smooth muscle cells of thoracic aorta of rat
马艳红 1王海昌2
作者信息
- 1. 北京军区261医院心血管内科
- 2. 710032,西安,第四军医大学西京医院心血管内科
- 折叠
摘要
Abstract
Objective To observe the effect of Salusin-β on c-fos, c-jun and proliferating cell nuclear antigen (PCNA) in vascular smooth muscle cells (VSMCs) of thoracic aorta of rat. Methods Fifty male Wistar rats were randomly divided into normal saline (NS)group (n=25) and Salusin-β group (n= 25) . Rats in Salusin-β group were injected Salusin-β(5nmol/kg) uia the femoral vein, while in NS group were injected equal amount of NS. All the rats were infused with paraform at 0.5, 1, 2, 4 and 24h after the injection, and then the thoracic aortas were harvested. The expressions of c-fos, c-jun and PCNA in VSMCs of rats' thoracic aorta were detected by immunocytochemistry and analyzed by Image-Pro Plus 5.0 image software. Results Compared with NS group, in Salusin-β group, the expression of c-fos at 1h and 2h, of c-jun at 1h, 2h and 4h, and of PCNA at 24h were up-regulated significantly (P＜0.0001). Conclusion Salusin-β may promote the proliferation of VSMCs.关键词
Salusin-β/血管平滑肌细胞/原癌基因蛋白质c-fos/原癌基因蛋白质c-jun/增殖细胞核抗原分类
医药卫生引用本文复制引用
马艳红,王海昌..Salusin-β对大鼠胸主动脉血管平滑肌细胞c-fos、c-jun和增殖细胞核抗原表达的影响[J].解放军医学杂志,2011,36(3):237-240,4.
