中国药理学通报2011，Vol.27Issue(6)：814-817,4.DOI:10.3969/j.issn.1001-1978.2011.06.018
碳酸酐酶抑制剂乙酰唑胺对切口痛大鼠痛行为的影响
Effects of carbonic anhydrase inhibitor acetazolamide on pain behavior in a rat model of incision pain
摘要
Abstract
Aim To observe the effect of carbonic anhydrase inhibitor acetazolamide ( ACT ) on the behavior of rats with incision pain. Methods All rats were intrathecally cathetered, six days later they were randomly divided into 5 groups with 16 rats in each group:sham, sham + ACT, incision pain, incision pain + low dose of ACT( 2.25 μg ), incision pain + high dose of ACT( 22.5 μg ). Rat' s incision pain model was established by using Brennan's method. ACT or vehicle was administered intrathecally 24 h after operation. Thermal withdrawal latency( TWL ) and mechanical withdrawal threshold( MWT ) were measured and compared 1 d before operation( baseline )and l d after operation( before drug injection and 30,75,120,165,240 min after drug injection ). Results The TWL and MWT were decreased significantly on 1 d after incision compared with baseline( P ＜ 0.05 ). Intrathecal administration of highdose ACT increased the TWL at 30, 75 and 120 min after drug injection( P ＜ 0.05 ). However, high dose ACT had no effect on the MWT. The TWL in incision + HACT group was significantly higher than that in incision group at 30, 75 and 120 min after drug injection ( P ＜ 0.05 ). Conclusions ACT at large dose can partially alleviate incision-induced heat hyperalgesia but has no effect on the mechanical hyperalgesia. Carbonic anhydrase might be involved in the development of heat hyperalgesia induced by incision.关键词
碳酸酐酶抑制剂/乙酰唑胺/γ氨基丁酸/疼痛/痛阈/痛觉过敏分类
医药卫生引用本文复制引用
韩潞潞,赵华平,薛庆生,于布为..碳酸酐酶抑制剂乙酰唑胺对切口痛大鼠痛行为的影响[J].中国药理学通报,2011,27(6):814-817,4.基金项目
国家自然科学基金资助项目(No 30672020) （No 30672020）
