中国药理学通报2011，Vol.27Issue(6)：835-839,5.DOI:10.3969/j.issn.1001-1978.2011.06.023
海参岩藻聚糖硫酸酯对小鼠急性酒精中毒防治作用的研究
Study on the preventive and therapeutic effects of fucoidan isolated from sea cucumber on acute alcoholism in mice
摘要
Abstract
Aim To study the preventive and therapeutic effects of fucoidan isolated from sea cucumber ( SC-FUC ) on acute alcoholism in mice.Methods Male ICR mice were randomly divided into five groups: normal control group, model control group, Yiganling positive control group, SC-FUC low and high dose groups (50 and 100 mg· kg-1 · d-1).The mice were treated daily by ig of SC-FUC, Yiganling or normal saline for 4 days.One hour after the last ig, the mice were given liquor ( 15 ml · kg-1 ).The time of drunkenness and sobriety were recorded.At the end of the experiment, the activities of alanine aminotransferase ( ALT )and aspartate aminotransferase ( AST ) in serum were tested and the effect of SC-FUC on the activities of alcohol dehydrogenase ( ADH ), acetaldehyde dehydrogenase ( ALD ), antioxidase and the content of malondialdehyde ( MDA ) in liver were observed.Results SC-FUC could put off the time of drunkenness and shorten the time of sobriety of mice.It could reduce the activities of ALT and AST in serum ( P ＜ 0.01 )and improve the activities of ADH, ALD and antioxidase in liver.The content of MDA was significantly decreased.Conclusion SC-FUC has good effects on drunkenness prevention and liver protection through the way of enhancing the metabolism of ethanol and the antioxidation ability in mice liver.关键词
海地瓜/岩藻聚糖硫酸酯/急性酒精中毒/肝脏/乙醇脱氢酶/乙醛脱氢酶/抗氧化分类
医药卫生引用本文复制引用
滕来宾,王静凤,杨延存,李冰,张珣,薛长湖..海参岩藻聚糖硫酸酯对小鼠急性酒精中毒防治作用的研究[J].中国药理学通报,2011,27(6):835-839,5.基金项目
海洋公益性行业科研专项资助项目(No 2010DFA31330,No 201105029) （No 2010DFA31330,No 201105029）
国家自然科学基金资助项目(No 30972284,30871944) （No 30972284,30871944）
"泰山学者"建设工程专项经费资助项目 （）
