中山大学学报（医学科学版）2011，Vol.32Issue(2)：253-255,262,4.
IL-17和IL-23在变应性鼻炎患者血清中的表达及意义
Expression Levels and Significance of IL-17 and IL-23 in Serum of Patients with Allergic Rhinitis
摘要
Abstract
[Objective]To investigate the expression levels of IL-17 and IL-23 in the serum of patients with allergic rhinitis and the correlation of levels of serum specific lgE , IL-17, and IL-23.[Methods]The samples were divided into two groups: the allergic rhinitis group (24 cases) and the normal control group (12 cases).The serum samples were obtained.The levels of serum specific IgE (sIgE) were detected by UniCAP system.The levels of IL -17 and IL-23 in serum were measured by enzyme-linked immunosorbent assay (ELISA).[Results]The levels of serum sIgE were 0 grade in the normal control and were 2 to 6 grades in the allergic rhinitis.The levels of IL-17 and IL-23 in serum were ( 165 ± 39) pg/mL and (79 ± 26) pg/mL in patients with allergic rhinitis, and were (68 ± 18) pg/mL and ( 14 ± 4) pg/mL in the normal controls.The levels of IL-17 and IL-23 were significantly elevated in the allergic rhinitis group as compared with the normal control group (P ＜ 0.05).In the allergic rhinitis group, correlation analysis showed that the level of IL- 17 was significantly positively correlated with the level of IL-23 and serum sIgE (r = 0.533 and 0.687, both P ＜ 0.01 ) and the level of IL-23 was significantly positively correlated with the level of serum slgE (r = 0.513, P ＜ 0.05).[Conclusion]IL-17 and IL-23 may play an important role in the pathogenesis of allergic rhinitis.关键词
白细胞介素-17/白细胞介素-23/变应性鼻炎分类
医药卫生引用本文复制引用
黄雪琨,陈玉莲,张革化,王涛,杨钦泰,李源..IL-17和IL-23在变应性鼻炎患者血清中的表达及意义[J].中山大学学报（医学科学版）,2011,32(2):253-255,262,4.基金项目
广东省科技计划项目(2009B030801087) （2009B030801087）
