实用医学杂志2011，Vol.27Issue(9)：1582-1585,4.DOI:10.3969/j.issn.1006-5725.2011.09.025
骨髓间充质干细胞上调再生障碍性贫血患者CD4+CD25+Foxp3+调节性T细胞的临床研究
Clinical research on mesenchymal stem cells in up-regulating CD4+CD25+FoxP3+ T regulatory cells in patients with aplastic anemia
刘增慧 1邝丽萍 1肖扬 1蒋祖军 1李力 1高扬 1李勇华 1李利 1庞妍 1欧阳玲1
作者信息
- 1. 510010,广州市,广州军区总医院血液科
- 折叠
摘要
Abstract
Objective To explore the levels of CD4+CD25+FoxP3+ T regulatory cells (Tregs) in peripheral hlood of aplastic anemia (AA) patients and its clinical value. To explore the possihle effects of applying exogenous bone marrow mesenchymal stem cells (MSC) on the expression of Tregs. Methods First, Tregs expressions were tested in 17 patients with chronic aplastic anemia (CAA), 13 patients with acute aplastic anemia (SAA) and 10 normal healthy donors by flow cytometry. Second, Tregs expressions were dynamic monitored in 7 CAA patients after treatment with MSC. Results The percentages of CD4+CD25+FoxP3+ Treg cells in peripheral blood of patients with AA (including CAA and SAA) were lower than that in normal control (P＜0.01); The percentage mentioned above in SAA was lower than that in CAA (P ＜ 0.05); The expression of Treg increased after treatment with MSC (P ＜ 0.05). Conclusions First, the percentage of CD4+CD25+FoxP3+Treg cells in AA patients is lower than normal, and its abnormal expression may be involved in the pathogenesis of AA. Second ,the much lower expression of Tregs in SAA makes it possible as a prognostic indicator. Third , MSC can upregulate the percentage of Tregs, which provides us a clue that it could be used to correct the immunological abnormalities in patients with AA.关键词
贫血,再生障碍性/间充质干细胞/调节性T细胞引用本文复制引用
刘增慧,邝丽萍,肖扬,蒋祖军,李力,高扬,李勇华,李利,庞妍,欧阳玲..骨髓间充质干细胞上调再生障碍性贫血患者CD4+CD25+Foxp3+调节性T细胞的临床研究[J].实用医学杂志,2011,27(9):1582-1585,4.
