分析化学2011，Vol.39Issue(2)：235-238,4.DOI:10.3724/SP.J.1096.2011.00235
气相色谱-质谱法检测人血清样品中新型含氯阻燃剂德克隆
Quantification of Dechlorane Plus in Human Serum by Gas Chromatography Coupled with Negative Chemical Ionization Mass Spectrometry
摘要
Abstract
A gas chromatography coupled with negative chemical ionization mass spectrometric(GCNCI-MS) method was developed for the determination of two dechlorane plus (DP) isomers in human serum sample. Target compound and serum lipid were extracted by lipid-lipid extraction. After the sulfuric acid treatment to remove extracted lipids from the samples, samples were further cleaned up with a silica/sulfuric acid column. Identification and quantification of DP were carried out by MS. The detection limit of instrument was 0. 5- 0. 7 pg. The detection limit of the method was 15-20 pg per sample. Spiked recoveries of DP in human serum samples were in the range of 70.2％-85.7％. The developed method was further validated in human serum. DP concentrations were analyzed in 20 electronics dismantling workers and 20 reference humans, total DP concentration was 7.8-465 ng/g lipid and 0.93-50.5 ng/g lipid, respectively.关键词
德克隆/新型有机污染物/气相色谱/负离子化学源/血清Key words
Dechlorane plus/ Emerging contaminant/ Gas chromatography/ Negative chemical ionization/ Human serum引用本文复制引用
任国发,罗湘凡,马盛韬,孙延枫,于志强,盛国英,傅家谟..气相色谱-质谱法检测人血清样品中新型含氯阻燃剂德克隆[J].分析化学,2011,39(2):235-238,4.基金项目
本文系国家973计划(No.2008CB418205)和有机地球化学国家重点实验室项目(No.OGL-200901)资助 （No.2008CB418205）
