中国当代儿科杂志2011，Vol.13Issue(3)：181-184,4.
缺氧性肺动脉高压新生儿血清HIF-1α、ET-1及Ca(2+)变化及意义
Serum levels of HIF-1α,ET-1 and Ca(2+)in neonates with hypoxic pulmonary hypertension
周英 1王乐 1李明霞1
作者信息
- 1. 新疆医科大学第一附属医院新生儿科,新疆,乌鲁木齐,830054
- 折叠
摘要
Abstract
Objective To study the changes and significance of serum hypoxia-inducible factor-1α (HIF-1α),endothelin-1 ( ET-1 ) and calcium ( Ca2+ ) levels in neonates with hypoxic pulmonary hypertension (HPH). Methods Seventy-five neonates with HPH (29 mild, 25 moderate and 21 severe) and 22 hospitalized neonates with non-HPH (control group ) were enrolled. Pulmonary artery systolic blood pressure (PASP) was measured by bedside echocardiography within 24 hrs after birth. Serum levels of HIF-1α and ET-1 were measured using ELASA. Serum Ca2+ concentrations were measured with ion selective electrode. Results Serum levels of HIF-1 α and ET-1 in the HPH group increased significantly compared with those in the control group (P ＜ 0.01 ), and were positively related with PASP (rHIF- 1α =0.75, P ＜ 0. 01; rET-1 =0. 56,P ＜0. 05 ). Serum Ca2+ levels in neonates with severe HPH were significantly lower than those in the control group ( P ＜ 0. 05 ). There were no correlation between serum Ca2+ levels and PASP.Conclusions Serum HIF-1α and ET-1 levels are positively related with PASP in neonates with HPH, suggesting that serum HIF-1α and ET-1 may be involved in the occurrence of neonatal HPH. Serum Ca2+ levels are reduced in severe neonates with HPH, suggesting that serum Ca2+ may play a role in the occurrence of severe HPH.关键词
缺氧性肺动脉高压/缺氧诱导因子/内皮素/钙离子/新生儿分类
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周英,王乐,李明霞..缺氧性肺动脉高压新生儿血清HIF-1α、ET-1及Ca(2+)变化及意义[J].中国当代儿科杂志,2011,13(3):181-184,4.
