中国当代儿科杂志2011，Vol.13Issue(3)：202-204,3.
毛细支气管炎患儿红细胞免疫及T细胞亚群变化的研究
Changes of red cell immune function and T-lymphocyte subsets in children with bronchiolitis
刘义红 1熊丽萍 1沈红元2
作者信息
- 1. 华中科技大学同济医学院附属孝感医院儿科,湖北,孝感,432000
- 2. 湖北职业技术学院医学院检验中心,湖北,孝感,432000
- 折叠
摘要
Abstract
Objective To study the changes of red cell immune function and T-lymphocyte subsets in children with bronchiolitis and their possible roles in the pathogenesis of bronchiolitis. Methods Forty-five children with bronchiolitis and 30 healthy controls were enrolled. Red cell immune complex rosette (RBC-1CR) and red cell C3b receptor rosette (RBC-C3bRR) were detected. The percentages of CD3 +, CD4 + and CD8 + cells were assayed by flow cytometry. Results RBC-C3 bRR [ ( 13.6 + 6.2 ) ％ vs ( 18.0 + 7.4 ) ％ ] and the percentage of CD8 + cells [ ( 21. 6 + 4.4 ) ％ vs ( 25.6 ±5.2 ) ％ ] in the bronchiolitis group were lower than those in the control group ( P ＜0.01 ). The percentage of CD3 + cells [ (59.9 +6.7)％ vs (52.1 +8.3)％ ] and CD4+ cells [ (53.5 ±6.2)％ vs (46.8 ±4.9)％ ] and RBC-ICR [ (8.3 ±3.5 ) ％ vs ( 6. 1 ± 2.5 ) ％ ] in the bronchiolitis group were higher than those in the control group ( P ＜ 0.0l ). The percentage of CD4 + cells was positively correlated with RBC-ICR ( r = 0. 63, P ＜ 0. 05 ) and negatively correlated with RBC-C3bRR ( r = -0.82,P ＜0. 0l ). Conclusions There are dysfunctions of red cell immune and T-lymphocyte subsets in children with brochiolitis, which may play a role in the pathogenesis of brochiolitis.关键词
毛细支气管炎/T淋巴细胞/红细胞免疫/儿童分类
医药卫生引用本文复制引用
刘义红,熊丽萍,沈红元..毛细支气管炎患儿红细胞免疫及T细胞亚群变化的研究[J].中国当代儿科杂志,2011,13(3):202-204,3.
