依达拉奉对惊厥持续状态幼年大鼠海马GFAP和IL-lβ表达及细胞凋亡的影响OA北大核心CSCDCSTPCD
Effects of edravone on glial fibrillary acidic protein and interleukin-1β expression and neuronal apoptosis in juvenile rat hippocampus after status convulsion
目的:观察幼年大鼠惊厥持续状态(SC)后海马胶质纤维酸性蛋白(GFAP)、白介素-1β(IL-1β)的表达及神经细胞凋亡的变化,并探讨依达拉奉(ED)对三者的影响.方法:将195只Sprague-Dawley幼年雄性大鼠随机分为生理盐水对照组(Ns组)、惊厥持续状态组(sc组)和依达拉奉干预组(ED组),每组65只,各组均按sc后处死时间分为4h、12h、24h、48h、72h 5个亚组.每组13只.采用氯化锂-匹鲁卡品制备幼年大鼠sC模型.应用…查看全部>>
Objective To study the effects of edaravone on glial fibrillary acidic protein (GFAP) and interleukin- 1β (IL-1β) expression and neuronal apoptosis in the juvenile rat hippocampus after status convulsion (SC). Methods One hundred and ninety-five juvenile male Sprague-Dawley (SD) rats were randomly divided into 3 groups: normal saline control and SC with and without edaravone treatment. Each of the 3 groups was further subdivided into subgroups sacrificed a…查看全部>>
王海萍;邓小龙;李光乾
浙江中医药大学附属杭州市第六医院/杭州市儿童医院神经科,浙江,杭州,310014武汉市儿童医院神经科,湖北,武汉,430016浙江中医药大学附属杭州市第六医院/杭州市儿童医院神经科,浙江,杭州,310014
医药卫生
惊厥持续状态胶质纤维酸性蛋白白介素-1β细胞凋亡依达拉奉大鼠
《中国当代儿科杂志》 2011 (3)
231-235,5
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